Synthesis of mono- and di-azido-hexopyranoses with N-alkyl and N,N-dialkyl amino groups at C-2 position: Intermediates for accessing new polyaminosugars t
نویسندگان
چکیده
Michael addition reactions of morpholine and benzylamine to methyl 2,3-dideoxy-4,6-0-(phenylmethylene)-3-Cphenylsulfonyl-a-D-erythro-hex-2-enopyranoside 9 furnish glucoderivatives 10 and 11. Desulfonation at C-3 followed by synthetic manipulation produces intermediates for generating various new modified monosaccharides carry ing N-alkyl and N,N-dialkyl amino groups at the C-2 position of hexopyranosides. This route also has the potential to furn ish naturally occurring diaminosugars such as tobrosamine.
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